ISDA: 9XTL

Deposition Date 2025-11-22

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9XTL

Keywords:

GENE REGULATION

Title:

crystal structure of WDR5 with Histone H3 Q5E peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.06 Å

R-Value Free:

0.19

R-Value Work:

0.14

R-Value Observed:

0.14

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:A, C (auth: B)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61964 Pfam ID:PF25175

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H3.3
Gene (Uniprot):H3-3A, H3-3B
Mutagens:Q5E
Chain IDs:B (auth: C), D
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P84243

Primary Citation

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Guo, D, Meng, Y, Yang, Q, Luo, S, Jiang, X, Zheng, Y, Wu, L, Li, S, Jiang, H, Li, S, Wang, Z, Li, M, Wu, Q, Xiao, L, Zhu, R, He, X, Hu, Y, Zhao, H, Ye, X, Tong, Y, Fang, J, Xu, D, Xu, J, Yuan, Y, Lu, Z.Show

Immunity 59 1811 1824.e7 (2026)

PMID: 42379164 DOI: 10.1016/j.immuni.2026.06.004

Primary Citation of related structures

Feedback Form