ISDA: 9XS6

Deposition Date 2025-11-20

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9XS6

Keywords:

OXIDOREDUCTASE

Title:

Factor inhibiting HIF-1 alpha in complex with Mn(II) and isofraxidin

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.46 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 41 21 2

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Hypoxia-inducible factor 1-al
Chain IDs:A
Chain Length:349
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1MCO

SO4

Primary Citation

Structural Insights into Metal-Chelating Natural Inhibitors of Factor Inhibiting HIF-1 alpha.

Akhsanitaqwim, Y, Nakashima, Y, Ikumi, N, Morita, H.Show

J.Nat.Prod. ? ? ? (2026)

PMID: 42455177 DOI: 10.1021/acs.jnatprod.6c00734

Primary Citation of related structures

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