9XRI image
Deposition Date 2025-11-19
Release Date 2026-04-01
Last Version Date 2026-04-01
Entry Detail
PDB ID:
9XRI
Keywords:
Title:
Crystal structure of MTH1 in complex with acoramidis bound at the active site and protein-protein interface (molar ratio 1:24)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
1.08 Å
R-Value Free:
0.17
R-Value Work:
0.15
R-Value Observed:
0.15
Space Group:
P 21 21 21
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Oxidized purine nucleoside tr
Gene (Uniprot):NUDT1
Chain IDs:A, B
Chain Length:156
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
Primary Citation
Identification of Acoramidis as a Repurposed Inhibitor of the DNA Sanitization Enzyme MutT Homologue 1.
Acs Pharmacol Transl Sci 9 698 705 (2026)
PMID: 41852632 DOI: 10.1021/acsptsci.5c00782
Primary Citation of related structures
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