ISDA: 9XPO

Deposition Date 2025-11-17

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9XPO

Keywords:

LYASE

Title:

Crystal structure of the HVM1 in complex with AKG, nickel and helvamide.

Biological Source:

Source Organism(s):

Aspergillus rugulosus (Taxon ID: 41736)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 21 2 21

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:lyase
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Aspergillus rugulosus

Ligand Molecules

A1E05

AKG

Primary Citation

Radical Mechanism and Stereochemical Control in Consecutive C-C Bond Formation by the Nonheme Iron Enzyme Hvm1.

Zhou, S, Zhang, J, Zuo, J.Y, Yu, J, Du, Y.F, Wang, R, Wu, C, Zhang, G, Shang, A, Zhou, P, Wang, Y, Zhang, Z.M, Li, H, Liu, H.Show

J.Am.Chem.Soc. 148 35399 35410 (2026)

PMID: 42677573 DOI: 10.1021/jacs.6c05166

Primary Citation of related structures

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