9XMJ image
Deposition Date 2025-11-10
Release Date 2026-04-29
Last Version Date 2026-04-29
Entry Detail
PDB ID:
9XMJ
Keywords:
DNA BINDING PROTEIN
Title:
A Potent and Selective ROR gamma Inhibitor for the Treatment of Autoimmune Diseases
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.18 Å
R-Value Free:
0.21
R-Value Work:
0.17
Space Group:
P 1 21 1
9XMJ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nuclear receptor ROR-gamma
Gene (Uniprot):RORC
Mutagens:R469A,R473A
Chain IDs:A, C, E, G
Chain Length:258
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P51449
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nuclear receptor corepressor
Gene (Uniprot):NCOR2
Chain IDs:B, D, F, H
Chain Length:22
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q9Y618
Ligand Molecules
A1MCM
Primary Citation
A potent and selective ROR gamma inhibitor for the treatment of autoimmune diseases.
Bioorg.Med.Chem.Lett. 132 130494 130494 (2026)
PMID: 41371311 DOI: 10.1016/j.bmcl.2025.130494
Primary Citation of related structures
9XMJ
Feedback Form
Name
Email
Institute
Feedback