9XL8 image
Deposition Date 2025-11-07
Release Date 2026-09-02
Last Version Date 2026-09-02
Entry Detail
PDB ID:
9XL8
Keywords:
IMMUNE SYSTEM
Title:
Crystal structure of the VHH and Trastuzumab-Fab complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Vicugna pacos (Taxon ID: 30538)
Expression System(s):
Cricetulus griseus, Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.00 Å
R-Value Free:
0.27
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
C 2 2 21
9XL8 validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Antibody
Chain IDs:A
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Antibody
Chain IDs:B
Chain Length:220
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Antibody
Chain IDs:C
Chain Length:118
Number of Molecules:1
Biological Source:Vicugna pacos
Primary Citation
Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities.
Protein Sci. 35 e70739 e70739 (2026)
PMID: 42559765 DOI: 10.1002/pro.70739
Primary Citation of related structures
9XL8
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