ISDA: 9XJW

Deposition Date 2025-11-05

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9XJW

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of GPR119 in complex with partial agonist AS1268574 and Gs protein

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.53 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAS
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63092 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nb35
Chain IDs:D (auth: N)
Chain Length:138
Number of Molecules:1
Biological Source:Lama glama

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucose-dependent insulinotro
Gene (Uniprot):GPR119
Chain IDs:E (auth: R)
Chain Length:335
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8TDV5 Pfam ID:PF00001

Ligand Molecules

A1E0J

Primary Citation

Cryo-EM structure of GPR119 in complex with partial agonist AS1268574 and Gs protein

Wu, S.Show

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