ISDA: 9XJ8

Deposition Date 2025-11-04

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9XJ8

Keywords:

CHAPERONE

Title:

Cryo-EM structure of Hsp90(E47A)-FKBP8 complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.09 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Heat shock protein HSP 90-alp
Mutagens:E47A
Chain IDs:A, B
Chain Length:732
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Isoform 2 of Peptidyl-prolyl
Chain IDs:C (auth: E)
Chain Length:281
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

ATP

Primary Citation

FKBP8 connects the Hsp70-Hsp90 chaperone machinery to the folding of membrane proteins.

Ge, M.X, Wu, M.Z, Ji, J, Li, Z.P, Bai, Z, He, J, Chuh, J, Zhang, Y, Li, J, Zhang, Z.R.Show

Nat Commun ? ? ? (2026)

PMID: 42321214 DOI: 10.1038/s41467-026-74519-6

Primary Citation of related structures

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