ISDA: 9XF4

Deposition Date 2025-10-28

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9XF4

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of Leu-enkephalin-BMS-986187-bound DOR-Gi2 complex

Biological Source:

Source Organism(s):

Escherichia coli (Taxon ID: 562)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.05 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,Delta
Gene (Uniprot):cybC, OPRD1
Chain IDs:A
Chain Length:595
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens, synthetic construct

UniProt ID:P0ABE7,P41143 Pfam ID:PF00001

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:384
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI2
Chain IDs:D
Chain Length:355
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P04899 Pfam ID:PF00503

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TYR-GLY-GLY-PHE-LEU
Chain IDs:E (auth: L)
Chain Length:5
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

A1D6B

Primary Citation

Molecular mechanism of allosteric modulation of opioid receptors.

Wang, H, Miao, Z, Zhao, C, Fu, H, Tian, X, Liu, X, Wang, L, Liu, Y, Liu, X, Yong, X, Su, L, Yan, W, Cheng, L, Chai, R, Shao, Z, Ke, B.Show

Signal Transduct Target Ther 11 ? ? (2026)

PMID: 42362532 DOI: 10.1038/s41392-026-02759-5

Primary Citation of related structures

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