ISDA: 9XD5

Deposition Date 2025-10-27

Release Date 2026-05-06

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9XD5

Keywords:

VIRAL PROTEIN/RNA

Title:

Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with the 5' vRNA

Biological Source:

Source Organism(s):

Crimean-Congo hemorrhagic fever virus strain IbAr10200 (Taxon ID: 652961)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.72 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RNA-directed RNA polymerase L
Gene (Uniprot):L
Chain IDs:A
Chain Length:3945
Number of Molecules:1
Biological Source:Crimean-Congo hemorrhagic fever virus strain IbAr10200

UniProt ID:Q6TQR6 Pfam ID:PF02338, PF15518, PF04196 EC:3.4.19.12,3.4.22.-,3.1.-.-,2.7.7.48

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*UP*CP*UP*CP*AP*AP*
Chain IDs:B (auth: C)
Chain Length:19
Number of Molecules:1
Biological Source:Crimean-Congo hemorrhagic fever virus strain IbAr10200

Ligand Molecules

Primary Citation

Structures and inhibition of the Crimean-Congo haemorrhagic fever virus polymerase.

Xue, L, Gui, J, Pan, H, Wu, F, Gao, S, Kuang, W, Chang, T, Li, Z, Zou, B, Zhao, H, Li, M, Zhou, M, Yuan, H, Rong, L, Gong, P, He, J, Deng, Z, Wang, M, Zhan, P, Chen, X, Xiong, X.Show

Nature ? ? ? (2026)

PMID: 42486991 DOI: 10.1038/s41586-026-10701-6

Primary Citation of related structures

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