9XC6 image
Deposition Date 2025-10-25
Release Date 2026-07-08
Last Version Date 2026-07-08
Entry Detail
PDB ID:
9XC6
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of BMS-986187-bound MOR-Gi1 complex
Biological Source:
Source Organism(s):
Oplophorus gracilirostris (Taxon ID: 727944)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.04 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9XC6 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:A
Chain Length:353
Number of Molecules:1
Biological Source:Oplophorus gracilirostris
UniProt ID:P63097 Pfam ID:PF00503 EC:3.6.5.-
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:335
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C
Chain Length:56
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mu-type opioid receptor
Gene (Uniprot):OPRM1
Chain IDs:D (auth: R)
Chain Length:281
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P35372 Pfam ID:PF00001
Ligand Molecules
A1D6B
A1ESG
Primary Citation
Molecular mechanism of allosteric modulation of opioid receptors.
Signal Transduct Target Ther 11 ? ? (2026)
PMID: 42362532 DOI: 10.1038/s41392-026-02759-5
Primary Citation of related structures
9XC6
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