ISDA: 9XC5

Deposition Date 2025-10-25

Release Date 2026-10-14

Last Version Date 2026-10-14

Entry Detail

PDB ID:

9XC5

Keywords:

PROTEIN BINDING

Title:

Crystal structure of PDE5A in complex with a flavonoid glycoside

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.69 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:cGMP-specific 3',5'-cyclic ph
Gene (Uniprot):PDE5A
Chain IDs:A
Chain Length:326
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O76074 EC:3.1.4.35

Ligand Molecules

GOL

Primary Citation

Mechanistic study of PDE5A inhibitors from the prepared folium of Epimedium sagittatum maxim.

Fang, Y, Wu, S, Xu, J, Chen, J, Shi, W, Wang, H, Li, S, Xie, H, Tao, H, Pan, L, Zang, Y, Yao, G, Zheng, X.Show

J.Struct.Biol. 218 108279 108279 (2026)

PMID: 41380862 DOI: 10.1016/j.jsb.2025.108279

Primary Citation of related structures

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