ISDA: 9XBZ

Deposition Date 2025-10-24

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9XBZ

Keywords:

ONCOPROTEIN

Title:

The crystal structure of KRAS G12R (GDP bound) in complex with RP03519

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.34 Å

R-Value Free:

0.23

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Mutagens:G12R
Chain IDs:A
Chain Length:170
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1EZK

GDP

Primary Citation

Discovery and Characterization of RP04340: A Highly Potent and Orally Active Pan-KRAS PROTAC Degrader

Ji, X, Du, Y, Zhang, Q, Zong, B, Du, K, He, X, Wu, G, Liang, C, Hu, Q, Zhang, Y, Li, H, Shen, L, Chen, Z, Bai, B, Wang, L, Ai, J, Zhang, L, Zhou, H, Sun, S, Wang, Y, Chang, Z, Wang, Z, Chen, D, Zhou, T, Kong, X, Lu, J.Show

J.Med.Chem. ? ? ? (2026)

DOI: 10.1021/acs.jmedchem.6c01832

Primary Citation of related structures

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