ISDA: 9X65

Deposition Date 2025-10-14

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9X65

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.19 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Potassium voltage-gated chann
Gene (Uniprot):KCNQ3
Chain IDs:E (auth: A), F (auth: B), G (auth: C)
Chain Length:872
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:O43525 Pfam ID:PF00520, PF03520, PF11956

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Potassium voltage-gated chann
Gene (Uniprot):KCNQ2
Chain IDs:H (auth: D)
Chain Length:872
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O43526 Pfam ID:PF00520, PF03520, PF16642, PF11956

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Calmodulin-1
Gene (Uniprot):CALM1
Chain IDs:A (auth: E), B (auth: F), C (auth: G), D (auth: H)
Chain Length:149
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P0DP23 Pfam ID:PF13499

Ligand Molecules