9X4F image
Deposition Date 2025-10-10
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
9X4F
Keywords:
LYASE
Title:
Crystal structure of tetrameric alpha-enolase with asymmetric flexible active sites
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.70 Å
R-Value Free:
0.24
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 1 21 1
9X4F validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Alpha-enolase
Gene (Uniprot):ENO1
Chain IDs:A, B, C, D
Chain Length:447
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P06733 Pfam ID:PF03952, PF00113 EC:4.2.1.11
Ligand Molecules
MG
Primary Citation
Natural Glycoside OSW-1 Targets Glycolytic Enzyme Enolase 1 to Reprogram Tumor Metabolism via Glycolytic Blockade.
Acs Chem.Biol. 21 790 800 (2026)
PMID: 41855411 DOI: 10.1021/acschembio.6c00022
Primary Citation of related structures
9X4F
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