ISDA: 9X2H

Deposition Date 2025-10-05

Release Date 2026-08-05

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9X2H

Keywords:

LIGASE

Title:

AARS1 bound with XY353

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alanine--tRNA ligase, cytopla
Gene (Uniprot):AARS1
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P49588 Pfam ID:PF01411 EC:6.1.1.7,6.-.-.-

Ligand Molecules

A1EYX

GOL

Primary Citation

Covalent allosteric inhibition of AARS1 lactyltransferase

Huang, Y, Liu, S, Tian, L, Tang, Y, Dou, Y, Wang, H, Zheng, T, Wang, M, Li, R, Wang, Z, Zhou, Z, Chen, X, Min, J.Show

Nat Commun 17 9864 ? (2026)

DOI: 10.1038/s41467-026-76732-9

Primary Citation of related structures

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