9X26 image
Deposition Date 2025-10-03
Release Date 2026-10-07
Last Version Date 2026-10-07
Entry Detail
PDB ID:
9X26
Keywords:
TRANSFERASE
Title:
Crystal structure of CDK12/Cyclin K in complex with covalent inhibitor ZLC853
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.28 Å
R-Value Free:
0.24
R-Value Work:
0.19
Space Group:
P 31 2 1
9X26 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclin-dependent kinase 12
Gene (Uniprot):CDK12
Chain IDs:A
Chain Length:324
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9NYV4 Pfam ID:PF00069 EC:2.7.11.22
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cyclin-K
Gene (Uniprot):CCNK
Chain IDs:B (auth: C)
Chain Length:244
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O75909 Pfam ID:PF00134, PF21797
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
TPO A THR modified residue
Ligand Molecules
A1EYW
Primary Citation
Discovery and preclinical evaluation of ZLC853 as a potential clinical candidate covalently targeting CDK12/13 kinases
Acta Pharm Sin B ? ? ? (2026)
DOI: 10.1016/j.apsb.2026.07.041
Primary Citation of related structures
9X26
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