ISDA: 9X20

Deposition Date 2025-10-03

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

9X20

Keywords:

SIGNALING PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of the GLP-1-bound human GLP-1R-Gi complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Trichoplusia ni, Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.18 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:C (auth: A)
Chain Length:353
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:D (auth: B)
Chain Length:353
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:E (auth: C)
Chain Length:67
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:F (auth: E)
Chain Length:247
Number of Molecules:1
Biological Source:synthetic construct

UniProt ID:9X20

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1(7-36)
Gene (Uniprot):GCG
Chain IDs:A (auth: P)
Chain Length:30
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01275 Pfam ID:PF00123

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Chain IDs:B (auth: R)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P43220 Pfam ID:PF02793, PF00002

Ligand Molecules

Primary Citation

Distinctive molecular architectures of G q - and G i -coupled GLP-1 receptors.

Zhou, Q, Li, J, Zhang, Y, Cai, X, Han, W, Yang, D, Wang, M.W.Show

Acta Pharm Sin B 16 1779 1785 (2026)

PMID: 41909725 DOI: 10.1016/j.apsb.2026.01.023

Primary Citation of related structures

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