9WZO image
Deposition Date 2025-09-29
Release Date 2026-10-07
Last Version Date 2026-10-07
Entry Detail
PDB ID:
9WZO
Keywords:
MEMBRANE PROTEIN
Title:
Crystal structure of 5-HT2AR in complex with antipsychotic drug pimavanserin
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.60 Å
R-Value Free:
0.26
R-Value Work:
0.24
R-Value Observed:
0.24
Space Group:
P 21 2 21
9WZO validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:5-hydroxytryptamine receptor
Gene (Uniprot):cybC, HTR2A
Mutagens:S162K,M164W,M1007W,R1098I,H1102I,R1106G,S372N
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens, Escherichia coli
UniProt ID:P28223,P0ABE7 Pfam ID:PF00001
Ligand Molecules
1PE
A1L11
CLR
MG
OLC
PEG
Primary Citation
Mechanisms Underlying Sustained Antidepressant Effects of Psychedelics Inspire Microdosing Strategies
To Be Published ? ? ? (?)
Primary Citation of related structures
9WZO
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