ISDA: 9WYE

Deposition Date 2025-09-26

Release Date 2026-02-11

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9WYE

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of HAstV1 spike

Biological Source:

Source Organism(s):

Human astrovirus 1 (Taxon ID: 12456)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.35 Å

R-Value Free:

0.17

R-Value Work:

0.14

R-Value Observed:

0.14

Space Group:

P 41 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein VP25
Gene (Uniprot):ORF2
Chain IDs:A
Chain Length:217
Number of Molecules:1
Biological Source:Human astrovirus 1

UniProt ID:O12792 Pfam ID:PF12226

Primary Citation

The conserved human astrovirus-receptor interface reveals a targetable vulnerability for antiviral development.

Wang, W, Xu, Y, Li, Z, Liu, D, Ma, K, Wang, R, Chen, R, Shu, B, Sun, X, Liu, Y, Ke, X, Zhang, S.Show

Nat Commun 17 ? ? (2026)

PMID: 41813687 DOI: 10.1038/s41467-026-70465-5

Primary Citation of related structures

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