ISDA: 9WTW

Deposition Date 2025-09-17

Release Date 2026-08-05

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9WTW

Keywords:

PROTEIN FIBRIL

Title:

Amyloid-beta 40 Flemish (A21G) mutant Filaments from Human Brain

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

1.98 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Amyloid-beta protein 40
Gene (Uniprot):APP
Chain IDs:A (auth: B), B (auth: J), C (auth: I), D (auth: H), E (auth: G), F (auth: A), G (auth: D), H (auth: C), I (auth: F), J (auth: E)
Chain Length:0
Number of Molecules:10
Biological Source:Homo sapiens

UniProt ID:P05067 Pfam ID:PF03494

Primary Citation

Distinct amyloid-beta filament fold in individuals with APP Flemish mutation.

Khaki, P.S.S, Guillen-Poza, P.A, Wong, C, Kan, C, Sharma, R, Sugimura, R, Robinson, A.C, Valbuena, A, Ng, R.C, Yang, Y, Hervas, R.Show

Nat.Struct.Mol.Biol. 33 1194 1203 (2026)

PMID: 42562893 DOI: 10.1038/s41594-026-01855-y

Primary Citation of related structures

Feedback Form