ISDA: 9WOX

Deposition Date 2025-09-07

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9WOX

Keywords:

PROTEIN BINDING

Title:

Crystal Structure of the MLH1 Protein Bound to the FAN1 Peptide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.05 Å

R-Value Free:

0.29

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

I 2 2 2

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:DNA mismatch repair protein M
Chain IDs:A, B
Chain Length:257
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Fanconi-associated nuclease 1
Chain IDs:C, D
Chain Length:60
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Structural insights into the MLH1-FAN1 interaction reveal an uncharacterized binding interface on MLH1.

Chen, Y, Hu, H, Shang, X, Fishwick, K.M, Greco, G, Xiao, Q, Zhou, Y, Huang, Q, Jiang, T, Huang, X, Wang, G, Zhen, X, Xu, G, Qin, S, Sartori, A.A, Liu, Y.Show

Nat Commun ? ? ? (2026)

PMID: 42409804 DOI: 10.1038/s41467-026-74991-0

Primary Citation of related structures

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