9WNT image
Deposition Date 2025-09-05
Release Date 2026-07-08
Last Version Date 2026-07-08
Entry Detail
PDB ID:
9WNT
Keywords:
IMMUNE SYSTEM
Title:
Crystal structure of SN45 TCR in complex with C14-Gly-Gly-Ser-Ile lipopeptide-bound Mamu-B*05104
Biological Source:
Source Organism(s):
Macaca mulatta (Taxon ID: 9544)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.70 Å
R-Value Free:
0.27
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 1 21 1
9WNT validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Gene (Uniprot):Mamu-B
Chain IDs:A, F
Chain Length:276
Number of Molecules:2
Biological Source:Macaca mulatta
UniProt ID:B2ZHY7
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:B, G
Chain Length:100
Number of Molecules:2
Biological Source:Macaca mulatta
UniProt ID:Q6V7J5 Pfam ID:PF07654
Protein Blast
Polymer Type:polypeptide(L)
Molecule:4-mer Lipopeptide
Chain IDs:C, H
Chain Length:4
Number of Molecules:2
Biological Source:synthetic construct
Protein Blast
Polymer Type:polypeptide(L)
Molecule:SN45 T cell receptor alpha ch
Chain IDs:D, I
Chain Length:197
Number of Molecules:2
Biological Source:Macaca mulatta
Protein Blast
Polymer Type:polypeptide(L)
Molecule:SN45 T cell receptor beta cha
Chain IDs:E, J
Chain Length:245
Number of Molecules:2
Biological Source:Macaca mulatta
Ligand Molecules
EDO
IOD
MYR
NA
Primary Citation
Lipopeptide ligands captured by MHC class I molecules undergo dynamic conformational changes that affect their antigenic strength.
J.Biol.Chem. 302 111049 111049 (2026)
PMID: 41391759 DOI: 10.1016/j.jbc.2025.111049
Primary Citation of related structures
9WNT
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