ISDA: 9WIK

Deposition Date 2025-08-28

Release Date 2026-07-01

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9WIK

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of GPR84-Gi complex with DL-175

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.30 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Mutagens:S47N/G203A/E45A/A326S
Chain IDs:A
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:B
Chain Length:382
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:C
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,G-pro
Chain IDs:D (auth: R)
Chain Length:691
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens, synthetic construct

Polymer Type:polypeptide(L)
Molecule:ScFv16
Chain IDs:E (auth: S)
Chain Length:248
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

A1MBR

Primary Citation

Mechanistic insight into signal bias by the agonist-dependent conformational dynamics of GPR84.

Suzuki, S, Tran, D.P, Nishikawa, K, Kitao, A, Fujiyoshi, Y.Show

Nat Commun ? ? ? (2026)

PMID: 42463693 DOI: 10.1038/s41467-026-75728-9

Primary Citation of related structures

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