ISDA: 9WIC

Deposition Date 2025-08-27

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9WIC

Keywords:

HYDROLASE

Title:

Crystal structure of the human dihydroorotase domain complexed with 5-aminoorotic acid reveals the loop in binding mode

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.83 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:CAD protein
Gene (Uniprot):CAD
Chain IDs:A
Chain Length:391
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P27708 Pfam ID:PF01979 EC:2.1.3.2

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
KCX	A	LYS	modified residue

Ligand Molecules

IJZ

Primary Citation

Structural basis of potent inhibition of the human CAD dihydroorotase domain by 5-aminoorotic acid.

Huang, Y.H, Huang, T.Y, Wang, M.C, Huang, C.Y.Show

Biochem.Biophys.Res.Commun. 787 152804 152804 (2025)

PMID: 41101239 DOI: 10.1016/j.bbrc.2025.152804

Primary Citation of related structures

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