ISDA: 9WFT

Deposition Date 2025-08-22

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9WFT

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of A0PKV-1 TCR in complex with HLA-A*11:01 bound to G12V-9 peptide(VVGAVGVGK)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Kirsten murine sarcoma virus (Taxon ID: 11808)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.09 Å

R-Value Free:

0.27

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:A0PKV-1 TCR beta chain
Chain IDs:D (auth: A)
Chain Length:260
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:A0PKV-1 TCR alpha chain
Chain IDs:E (auth: B)
Chain Length:219
Number of Molecules:1
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:HLA class I histocompatibilit
Chain IDs:A (auth: H)
Chain Length:276
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Chain IDs:B (auth: L)
Chain Length:100
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:G12V9
Chain IDs:C (auth: P)
Chain Length:9
Number of Molecules:1
Biological Source:Kirsten murine sarcoma virus

Primary Citation

Commensal Clostridium spp. harbor mimetic CTL-epitopes eliciting T cells cross-recognizing KRAS-G12V tumor neoantigen

Jin, X.Y, Wang, W.L, Zhang, Z.Y, Gu, Y.H, Xi, Y.H, Jiang, M, Peng, Y.Q, Yao, P.J, Tang, L.F, Ma, K.K, Wang, J, Li, F.Y, Li, X.W, Jin, W.J, Chen, Y, Chai, Y, Qi, J.X, Zhang, C.W.H, Liu, K.F, Wang, J, Gao, G.F, Tan, S.G.Show

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Primary Citation of related structures

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