ISDA: 9WE2

Deposition Date 2025-08-19

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9WE2

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of HLA-A*11:01 bound to A0PXA8-V2 peptide(IVGAVGIAK)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Clostridium (Taxon ID: 1485)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.19 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:HLA class I histocompatibilit
Chain IDs:A, D
Chain Length:276
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Chain IDs:B, E
Chain Length:100
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:A0PXA8-V2
Mutagens:T2V
Chain IDs:C, F
Chain Length:9
Number of Molecules:2
Biological Source:Clostridium

Primary Citation

Commensal Clostridium spp. harbor mimetic CTL-epitopes eliciting T cells cross-recognizing KRAS-G12V tumor neoantigen

Jin, X.Y, Wang, W.L, Zhang, Z.Y, Gu, Y.H, Xi, Y.H, Jiang, M, Peng, Y.Q, Yao, P.J, Tang, L.F, Ma, K.K, Wang, J, Li, F.Y, Li, X.W, Jin, W.J, Chen, Y, Chai, Y, Qi, J.X, Zhang, C.W.H, Liu, K.F, Wang, J, Gao, G.F, Tan, S.G.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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