9WDO image
Deposition Date 2025-08-19
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
9WDO
Keywords:
TRANSFERASE
Title:
Cryo-EM structure of the human PKR tetramer with mitapivat (C2 symmetric, dual-bound state)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.57 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9WDO validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Pyruvate kinase PKLR
Chain IDs:A, B, C, D
Chain Length:574
Number of Molecules:4
Biological Source:Homo sapiens
Ligand Molecules
WV2
Primary Citation
Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists
To Be Published ? ? ? (?)
Primary Citation of related structures
9WDO
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