ISDA: 9WDH

Deposition Date 2025-08-19

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9WDH

Keywords:

LIGASE

Title:

Crystal Structure of CBL-B in Complex with a Potent Inhibitor Demonstrating In Vivo Efficacy

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.80 Å

R-Value Free:

0.30

R-Value Work:

0.28

R-Value Observed:

0.28

Space Group:

P 1 21 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase C
Chain IDs:A, B
Chain Length:394
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1EVY

Primary Citation

A Unified 3D Molecular Generation Platform for Novel Scaffold Discovery and Hit-to-Lead Optimization Leading to Cbl-b Inhibitor Discovery with In Vivo Efficacy

Wang, H, Sun, G, Zhang, B, Wang, Y, Xin, B, Yang, M, Liu, C, Zhou, F, Liu, Z, Jiang, D, Wang, H, Zhou, W, Huang, B.Show

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