ISDA: 9WDF

Deposition Date 2025-08-19

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9WDF

Keywords:

STRUCTURAL PROTEIN

Title:

Crystal structure of PAK4-KPT-7523 complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):PAK4
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:292
Number of Molecules:12
Biological Source:Homo sapiens

UniProt ID:O96013 Pfam ID:PF00069 EC:2.7.11.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
SEP	A	SER	modified residue

Ligand Molecules

A1MBG

Primary Citation

Structural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor.

Park, J, Hong, H.R, Han, S.H, Song, J, Son, S.Y, Choi, S, Park, S.M, Lee, W.K, Jiko, C, Kim, J.H, Jee, J.G, Bang, J.K, Park, I.Y, Lee, S.J.Show

Acta Crystallogr D Struct Biol ? ? ? (2026)

PMID: 42473948 DOI: 10.1107/S2059798326006145

Primary Citation of related structures

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