ISDA: 9WDD

Deposition Date 2025-08-19

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9WDD

Keywords:

TRANSFERASE

Title:

Crystal structure of NAMPT-KPT-7523 complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.45 Å

R-Value Free:

0.19

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nicotinamide phosphoribosyltr
Gene (Uniprot):NAMPT
Chain IDs:A, B
Chain Length:491
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P43490 Pfam ID:PF18127, PF04095 EC:2.4.2.12

Ligand Molecules

A1MBG

Primary Citation

Structural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor.

Park, J, Hong, H.R, Han, S.H, Song, J, Son, S.Y, Choi, S, Park, S.M, Lee, W.K, Jiko, C, Kim, J.H, Jee, J.G, Bang, J.K, Park, I.Y, Lee, S.J.Show

Acta Crystallogr D Struct Biol ? ? ? (2026)

PMID: 42473948 DOI: 10.1107/S2059798326006145

Primary Citation of related structures

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