ISDA: 9W9S

Deposition Date 2025-08-10

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9W9S

Keywords:

PROTEIN FIBRIL

Title:

ATTRv-A97S type II filament from gastrocnemius muscle biopsy of an individual with a A97S mutation.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.61 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transthyretin
Gene (Uniprot):TTR
Chain IDs:A (auth: B), B (auth: A), C
Chain Length:127
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:P02766 Pfam ID:PF00576

Ligand Molecules

Primary Citation

Cryo-EM Structures of Biopsy-derived TTR Fibrils in Hereditary Transthyretin Amyloidosis

Zheng, Y, Liang, J, Li, Z, Liu, Y, Chu, X, Zhang, S, Wang, W, Bao, J, Liu, B, Ma, C, Yin, G, Deng, J, Chi, W, Meng, L, Shi, Y.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-75850-8

Primary Citation of related structures

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