ISDA: 9W9C

Deposition Date 2025-08-09

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9W9C

Keywords:

MEMBRANE PROTEIN

Title:

Structure of the apo state of human betaine/GABA transporter 1 in the occluded conformation

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Escherichia coli K-12 (Taxon ID: 83333)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.02 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:GFP,Maltose/maltodextrin-bind
Gene (Uniprot):malE, SLC6A12
Chain IDs:A
Chain Length:1291
Number of Molecules:1
Biological Source:Homo sapiens, Escherichia coli K-12

UniProt ID:P0AEX9,P48065 Pfam ID:PF01547, PF00209 EC:7.5.2.1

Ligand Molecules

Primary Citation

Substrate recognition and allosteric inhibition of human betaine/GABA transporter 1

Zhou, J, Liu, J, Jin, Y, Wang, Q, Yu, H, Wu, J.X.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-72924-5

Primary Citation of related structures

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