9W81 image
Deposition Date 2025-08-07
Release Date 2026-08-12
Last Version Date 2026-08-12
Entry Detail
PDB ID:
9W81
Keywords:
TRANSLOCASE
Title:
Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator FT-4202
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.81 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9W81 validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Pyruvate kinase PKLR
Chain IDs:A, B, C, D
Chain Length:574
Number of Molecules:4
Biological Source:Homo sapiens
Ligand Molecules
A1EVM
Primary Citation
Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists
To Be Published ? ? ? (?)
Primary Citation of related structures
9W81
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