ISDA: 9W5P

Deposition Date 2025-08-01

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9W5P

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of KRED

Biological Source:

Source Organism(s):

Novosphingobium aromaticivorans DSM 12444 (Taxon ID: 279238)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.53 Å

R-Value Free:

0.27

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Short-chain dehydrogenase/red
Gene (Uniprot):Saro_3543
Chain IDs:A, B, C, D
Chain Length:259
Number of Molecules:4
Biological Source:Novosphingobium aromaticivorans DSM 12444

UniProt ID:A4XEP2 Pfam ID:PF13561

Primary Citation

Chemo-Enzymatic Synthesis of a Squalamine Intermediate by an Engineered Ketoreductase from Novosphingobium aromaticivorans

Zhang, Z, Zhang, Y, Du, Z, Zheng, X, Xu, H, Lin, Y, Kong, P, Li, H, Cao, J, Zhang, C, Li, S, Xu, Y, Zhang, L.Show

Acs Catalysis 16 11618 11630 (2026)

DOI: 10.1021/acscatal.6c03102

Primary Citation of related structures

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