ISDA: 9W5I

Deposition Date 2025-08-01

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9W5I

Keywords:

CHAPERONE

Title:

AGO maturation complex (AMC): AGO2-miRNA duplex in complex with Hsp90 beta and co-chaperone p23

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.63 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Heat shock protein HSP 90-bet
Gene (Uniprot):HSP90AB1
Chain IDs:A, B
Chain Length:724
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P08238 Pfam ID:PF13589, PF00183 EC:3.6.4.10

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Prostaglandin E synthase 3
Gene (Uniprot):PTGES3
Chain IDs:C
Chain Length:160
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15185 Pfam ID:PF04969

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein argonaute-2
Gene (Uniprot):AGO2
Chain IDs:D
Chain Length:859
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UKV8 Pfam ID:PF16486, PF08699, PF02170, PF16488, PF16487, PF02171

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*UP*GP*AP*GP*GP*UP
Chain IDs:E
Chain Length:22
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*CP*UP*AP*UP*AP*CP
Chain IDs:F
Chain Length:22
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

ATP

Primary Citation

Structural basis for chaperone-guided RISC assembly

Jeong, M.-S, Lee, Y.-Y, Lee, H, Lee, J.-H, Lee, D, Kim, V.N, Roh, S.-H.Show

To be published ? ? ? (?)

Primary Citation of related structures

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