9W4Q image
Deposition Date 2025-08-01
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9W4Q
Keywords:
TRANSLOCASE
Title:
Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator SNH-119014
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.77 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9W4Q validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pyruvate kinase PKLR
Gene (Uniprot):PKLR
Chain IDs:A, B, C, D
Chain Length:574
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P30613 Pfam ID:PF00224, PF02887 EC:2.7.1.40
Ligand Molecules
A1EU3
Primary Citation
Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists
To Be Published ? ? ? (?)
Primary Citation of related structures
9W4Q
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