ISDA: 9W4K

Deposition Date 2025-07-31

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9W4K

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of inhibitor E822-1968 bound human urea transporter A2.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

CELL

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Urea transporter 2
Gene (Uniprot):SLC14A2
Chain IDs:A, B, C
Chain Length:397
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:Q15849 Pfam ID:PF03253

Ligand Molecules

A1EU8

Primary Citation

Hotspot pocket-based discovery of urea transporter selective inhibitors.

Liu, L, Li, Z, Zhang, C, Zhang, Y, Huang, Z, Zhang, D, Li, D, Zhao, J, Miao, Y, Cai, B, Zhu, K, Sun, J.P, Hou, G, Sun, Y, Yang, B, Yu, X, Huang, S.Show

Nat Commun 17 ? ? (2026)

PMID: 42009654 DOI: 10.1038/s41467-026-71834-w

Primary Citation of related structures

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