ISDA: 9W41

Deposition Date 2025-07-30

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9W41

Keywords:

MEMBRANE PROTEIN/IMMUNE SYSTEM

Title:

Structure of adenosine A2AR with an agonist MRS3997

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.71 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Mutagens:G49D,E50N,A249D,S252D,I372A,V375I,L272D
Chain IDs:A
Chain Length:243
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:D (auth: B)
Chain Length:366
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:C (auth: D)
Chain Length:289
Number of Molecules:1
Biological Source:Mus musculus

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:B (auth: G)
Chain Length:73
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,Adeno
Gene (Uniprot):cybC, ADORA2A
Mutagens:M7W,H102I,R106L
Chain IDs:E (auth: R)
Chain Length:607
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens

UniProt ID:P0ABE7,P29274 Pfam ID:PF00001

Ligand Molecules