ISDA: 9W3O

Deposition Date 2025-07-29

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9W3O

Keywords:

VIRAL PROTEIN

Title:

Crystal Structure of Human rhinovirus A2 3C Protease in Complex with a Broad-spectrum Inhibitor

Biological Source:

Source Organism(s):

rhinovirus A2 (Taxon ID: 12130)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.76 Å

R-Value Free:

0.26

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protease 3C
Chain IDs:A, B
Chain Length:180
Number of Molecules:2
Biological Source:rhinovirus A2

UniProt ID:P04936 EC:3.4.22.28

Ligand Molecules

A1EYZ

Primary Citation

Harnessing AI, Structural Biology, and Medicinal Chemistry to Overcome Viral Diversity: Broad-Spectrum 3C/3CL Protease Inhibitors Effective Across Pisoniviricetes

Liu, L, Wang, J.L, Wang, S.H, Dai, W.H, Zhang, X.L, Bai, F, Liu, H.Show

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