ISDA: 9W3B

Deposition Date 2025-07-29

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9W3B

Keywords:

VIRAL PROTEIN

Title:

Crystal Structure of Enterovirus A71 3C Protease in Complex with a Broad-spectrum Inhibitor

Biological Source:

Source Organism(s):

Human enterovirus 71 (strain BRCR) (Taxon ID: 69153)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.59 Å

R-Value Free:

0.23

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 43 3 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protease 3C
Chain IDs:A
Chain Length:204
Number of Molecules:1
Biological Source:Human enterovirus 71 (strain BRCR)

UniProt ID:Q66478 EC:3.4.22.29

Ligand Molecules

A1EYZ

Primary Citation

Harnessing AI, Structural Biology, and Medicinal Chemistry to Overcome Viral Diversity: Broad-Spectrum 3C/3CL Protease Inhibitors Effective Across Pisoniviricetes

Liu, L, Wang, J.L, Wang, S.H, Dai, W.H, Zhang, X.L, Bai, F, Liu, H.Show

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