ISDA: 9W2O

Deposition Date 2025-07-28

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9W2O

Keywords:

VIRAL PROTEIN

Title:

Crystal Structure of Norovirus 3C-like Protease in Complex with a Broad-spectrum Inhibitor

Biological Source:

Source Organism(s):

Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Taxon ID: 524364)

Expression System(s):

Escherichia coli bl21

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.76 Å

R-Value Free:

0.22

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 65 2 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like protease
Gene (Uniprot):ORF1
Chain IDs:A
Chain Length:188
Number of Molecules:1
Biological Source:Norovirus (strain Human/NoV/United States/Norwalk/1968/GI)

UniProt ID:Q83883 EC:3.4.22.66

Ligand Molecules

A1EYZ

Primary Citation

Harnessing AI, Structural Biology, and Medicinal Chemistry to Overcome Viral Diversity: Broad-Spectrum 3C/3CL Protease Inhibitors Effective Across Pisoniviricetes

Liu, l, Wang, j.l, Wang, s.h, Dai, w.h, Zhang, x.l, Bai, f, Liu, h.Show

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