ISDA: 9W2J

Deposition Date 2025-07-28

Release Date 2026-06-17

Last Version Date 2026-06-17

Entry Detail

PDB ID:

9W2J

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of Peptide 383 (P383)-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens, Trichoplusia ni, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.82 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A
Chain Length:229
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:E (auth: B)
Chain Length:358
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ASP-LYS-PHE-THR-GLY-MLE-A1EUR
Chain IDs:F (auth: C)
Chain Length:8
Number of Molecules:1
Biological Source:synthetic construct

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:B (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody 35
Chain IDs:C (auth: N)
Chain Length:134
Number of Molecules:1
Biological Source:Lama glama

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Substance-K receptor
Gene (Uniprot):TACR2
Chain IDs:D (auth: R)
Chain Length:406
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P21452 Pfam ID:PF00001

Ligand Molecules

Primary Citation

Mechanistic basis for activation and selectivity of NK2R by endogenous and synthetic peptide agonists

Ren, Y, Pavlovskyil, A, Liu, X, Gerhart-Hines, Z.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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