9W2F image
Deposition Date 2025-07-27
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9W2F
Keywords:
RNA BINDING PROTEIN
Title:
Cryo-EM structure of DDB1-CRBN in complex with dHuR-2 and HuR
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Insect cell expression vector ptie1, Cloning vector pet-t7p(-3g)-laco(symr+1)-gfp-lva
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9W2F validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:A
Chain Length:1140
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q16531 Pfam ID:PF10433, PF23726, PF03178
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Gene (Uniprot):CRBN
Chain IDs:B
Chain Length:381
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96SW2 Pfam ID:PF02190, PF03226
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ELAV-like protein 1
Gene (Uniprot):ELAVL1
Chain IDs:C
Chain Length:85
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15717 Pfam ID:PF00076
Ligand Molecules
A1EUN
ZN
Primary Citation
Molecular Glue Degraders of HuR Suppress BRAF-Mutant Colorectal Cancer
To Be Published ? ? ? (?)
Primary Citation of related structures
9W2F
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