ISDA: 9W26

Deposition Date 2025-07-26

Release Date 2026-03-11

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9W26

Keywords:

ANTIVIRAL PROTEIN

Title:

Cryo-EM structure of TasH-tigRNA (5G)-dsDNA complex

Biological Source:

Source Organism(s):

Salicola phage CGphi29 (Taxon ID: 754067)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.62 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TasH
Chain IDs:A, B
Chain Length:354
Number of Molecules:2
Biological Source:Salicola phage CGphi29

UniProt ID:9W26

Polymer Type:polyribonucleotide
Molecule:RNA (36-MER)
Chain IDs:C
Chain Length:37
Number of Molecules:1
Biological Source:Salicola phage CGphi29

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (38-MER)
Chain IDs:D, E
Chain Length:38
Number of Molecules:2
Biological Source:Salicola phage CGphi29

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (38-MER)
Chain IDs:F
Chain Length:38
Number of Molecules:1
Biological Source:Salicola phage CGphi29

Ligand Molecules

Primary Citation

Molecular basis for dual-spacer-guided target cleavage by the TIGR-TasH system.

Yang, J, Wang, T, Liu, Z, Wu, W, Sun, Y, Zhan, Y, Zhang, S, Chen, H, Liu, B, Yue, C, Yin, Z, Shan, Z, Li, X, Li, Z, Yuan, Z, Yin, H, Zhang, H.Show

Mol. Cell 86 1217 1229.e6 (2026)

PMID: 41831437 DOI: 10.1016/j.molcel.2026.02.017

Primary Citation of related structures

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