ISDA: 9W19

Deposition Date 2025-07-25

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9W19

Keywords:

TRANSFERASE

Title:

Crystal structure of FGFR2 with a macrocyclic compound XS8148

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.63 Å

R-Value Free:

0.27

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fibroblast growth factor rece
Gene (Uniprot):FGFR2
Chain IDs:A, B
Chain Length:313
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P21802 Pfam ID:PF07714 EC:2.7.10.1

Ligand Molecules

A1EUM

GOL

SO4

Primary Citation

Crystal structure of FGFR2 with a macrocyclic compound XS8148

Chen, X.J, Zhang, L, Chen, Y.H.Show

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