ISDA: 9W12

Deposition Date 2025-07-25

Release Date 2026-03-18

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9W12

Keywords:

TRANSCRIPTION

Title:

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with ZOL-P

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.75 Å

R-Value Free:

0.19

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

C 2 2 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Estrogen receptor
Gene (Uniprot):ESR1
Mutagens:Y537S
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P03372 Pfam ID:PF00104

Ligand Molecules

A1ET8

EDO

PEG

SO4

Primary Citation

A distinct zearalenone detoxification strategy mediated by cytochrome P450.

Liu, Z, Peng, R, Li, Q, Chen, C.C, Xin, L, Li, K, Huang, J.W, Liu, X, Zhang, X, Hu, L, Luo, S, Zhou, H, Li, A, Min, J, Guo, R.T.Show

Food Chem 510 148697 148697 (2026)

PMID: 41795529 DOI: 10.1016/j.foodchem.2026.148697

Primary Citation of related structures

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