9W0M image
Deposition Date 2025-07-24
Release Date 2026-06-03
Last Version Date 2026-06-03
Entry Detail
PDB ID:
9W0M
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of S1P2 in complex with heterotrimeric G protein
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.80 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9W0M validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sphingosine 1-phosphate recep
Gene (Uniprot):S1PR2
Chain IDs:A
Chain Length:405
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O95136 Pfam ID:PF00001
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:B (auth: C)
Chain Length:54
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Mutagens:S47C/G202T/G203A/E245A/A326S
Chain IDs:D
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63096 Pfam ID:PF00503
Ligand Molecules
NA
Primary Citation
Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3.
Protein Cell ? ? ? (2025)
PMID: 40851516 DOI: 10.1093/procel/pwaf068
Primary Citation of related structures
9W0M
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