ISDA: 9VUW

Deposition Date 2025-07-14

Release Date 2026-02-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9VUW

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SARS-CoV-2 main protease with a deletion of Asn51

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.60 Å

R-Value Free:

0.21

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Chain IDs:A
Chain Length:305
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48

Primary Citation

An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases.

Zeng, R, Cui, S, Xia, X, Huang, C, Sun, J, Deng, X, Gui, Q, Fan, H, Liu, X, Yu, Y, Yang, S, Lei, J.Show

Plos Pathog. 22 e1013981 e1013981 (2026)

PMID: 41734227 DOI: 10.1371/journal.ppat.1013981

Primary Citation of related structures

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