ISDA: 9VUU

Deposition Date 2025-07-14

Release Date 2026-02-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9VUU

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of SADS-CoV main protease (Lys35Val) in complex with 27h

Biological Source:

Source Organism(s):

Swine acute diarrhea syndrome coronavirus (Taxon ID: 2032731)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.40 Å

R-Value Free:

0.22

R-Value Work:

0.16

R-Value Observed:

0.17

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ORF1ab polyprotein
Gene (Uniprot):orf1ab
Mutagens:K35V
Chain IDs:A, B
Chain Length:302
Number of Molecules:2
Biological Source:Swine acute diarrhea syndrome coronavirus

UniProt ID:A0A2P1G738 Pfam ID:PF05409

Ligand Molecules

OF9

Primary Citation

An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases.

Zeng, R, Cui, S, Xia, X, Huang, C, Sun, J, Deng, X, Gui, Q, Fan, H, Liu, X, Yu, Y, Yang, S, Lei, J.Show

Plos Pathog. 22 e1013981 e1013981 (2026)

PMID: 41734227 DOI: 10.1371/journal.ppat.1013981

Primary Citation of related structures

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